Receptors functionalized with chiral aza-crown ether rings. Attempted enantioselective catalysis of a Michael addition reaction
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چکیده
منابع مشابه
Squaramide-catalysed asymmetric cascade aza-Michael/Michael addition reaction for the synthesis of chiral trisubstituted pyrrolidines.
A bifunctional squaramide catalysed aza-Michael/Michael cascade reaction between nitroalkenes and tosylaminomethyl enones or enoates has been developed. This organocatalytic cascade reaction provides easy access to highly functionalized chiral pyrrolidines with a broad substrate scope, giving the desired products in good yields (up to 99%) with good diastereoselectivities (up to 91 : 9 dr) and ...
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An efficient and enantioselective strategy to synthesize benzoindolizidines from α,β-unsaturated amino ketones via domino intramolecular aza-Michael addition/alkylation was developed. These reactions were enabled by cinchona alkaloid-derived quaternary ammonium salts as the phase-transfer catalyst. A variety of benzoindolizidines were prepared in good yields (up to 93%) and enantioselectivities...
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The catalytic asymmetric aza-Michael reaction of benzoyl hydrazine toward chalcones through the nonactivated amine moiety conjugated addition was facilitated by the developed N,N'-dioxide-Sc(OTf)(3) complex under mild conditions, affording the pharmacologically and synthetically useful products in moderate to high yields with up to 97% ee.
متن کاملEnantioselective Michael Addition of Water
The enantioselective Michael addition using water as both nucleophile and solvent has to date proved beyond the ability of synthetic chemists. Herein, the direct, enantioselective Michael addition of water in water to prepare important β-hydroxy carbonyl compounds using whole cells of Rhodococcus strains is described. Good yields and excellent enantioselectivities were achieved with this method...
متن کاملN-heterocyclic carbene-catalyzed aza-Michael addition.
Aza-Michael addition of amines, including aromatic and aliphatic amines, with α, β-unsaturated ketones was realized employing N-Heterocyclic Carbene (NHC) as organocatalyst, yielding β-amino ketones with up to 98% yield.
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ژورنال
عنوان ژورنال: Recueil des Travaux Chimiques des Pays-Bas
سال: 2010
ISSN: 0165-0513
DOI: 10.1002/recl.19961150704